Is it important?
If it's not important then it can be discarded.
But if it is important, is it knowable?

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'In Seeking Wisdom', the author Peter Bevelin quotes Warren Buffett:

There are two questions you ask yourself as you look at the decision you'll make.

Is it knowable?
Is it important?

If it is not knowable, as you know there are all kinds of things that are important but not knowable, we forget about those. And if it's unimportant, whether it's knowable or not, it won't make any difference. We don't care. But there are enough things that are knowable and important that we focus on those things. And everything else, we forget about.